Abstract From the #EndSARS protest of October 2020 to the emergence of unknown gunmen as well as the era of IPOB sit-at-home enforcement, the South-East Region of Nigeria has not known peace. Federal government critical infrastructures and security personnel located within the zone have been targeted by hoodlums through arson, vandalism and killings. The Federal Government on her own had over-flooded the zone with military operatives in an attempt to fish out the unknown gunmen and neutralize them. This paper attempts an analysis of the implications of the attacks by EndSARS protesters and Unknown Gunmen on Security Institutions for the socio-economic development of South-Eastern Nigeria. It adopted a qualitative method with reliance on secondary sources of data and observed that perceived injustice and the exclusion of the youths from the zone in the governance process particularly by the Buhari-led government constitutes one of the triggers of violence in the zone. It also uncovered that conflict entrepreneurs in political power in the region have cashed into the already tensed security situation in the zone to escalate the killings through sponsored assassinations with attendant damages to the socio-economic fabrics of the zone. The paper concludes that only a meaningful dialogue between government and the people of the zone will stem the tide of violence and insecurity in the South East geopolitical zone of Nigeria. Keywords:#EndSARS, Unknown Gunmen, South-East Nigeria, Implications..